Exhaled Breath Biomarker May Detect Lung Cancer
(Chicago, Illinois) October 28, 2013—Researchers at Cleveland Clinic recently discovered that lung cancer may be detected in patients by testing their exhaled breath. Preliminary studies suggest that an accurate exhaled breath biomarker could be developed for use as a clinical test. Findings were presented at CHEST 2013 in Chicago, Illinois.
“We believe that cancer cells release a unique chemical signature related to the tumor-growing process,” said Peter J. Mazzone, MD, FCCP, director of the lung cancer program for the Respiratory Institute at Cleveland Clinic. “We are currently developing a breath-based test based on the results of our research.”
Dr. Mazzone and his colleagues studied 82 people with biopsy-confirmed lung cancer who had not yet received treatment against a control group of 155 people who were either at-risk for lung cancer or who had benign lung nodules. Subjects were asked to breathe normally while their breath was exposed to a high-dimensional chemical sensor called a colorimetric sensor array. The colors on the array change when exposed to various chemicals. If the chemicals in the breath contained markers for lung cancer, the array would show that in a pattern of color changes. The colorimetric sensor array continually monitored the chemicals exhaled from the breath of the subjects, resulting in sensor changes that accurately distinguished the breath of people with lung cancer from the controls.
“Lung cancer is the leading cause of cancer death in the United States,” said Michael H. Baumann, MD, MS, FCCP, president-elect, ACCP. “We welcome the cutting-edge research that can help in diagnosis and treatment of this devastating illness.”
CHEST 2013 is the 79th annual meeting of the American College of Chest Physicians, held October 26-31 in Chicago, Illinois. The ACCP is the global leader in clinical chest medicine, representing 18,700 members who provide patient care in the areas of pulmonary, critical care, and sleep medicine in the United States and throughout the world. The mission of the ACCP is to promote the prevention, diagnosis, and treatment of chest diseases through education, communication, and research. For information about the ACCP, visit the ACCP website at www.chestnet.org, or follow the ACCP on Facebook and Twitter and the meeting hashtag, #CHEST2013.
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